The presentation will focus on the advantages of piezoelectric instrumentation in oral and maxillofacial surgery, emphasizing its precision, selective cutting properties, reduced trauma to surrounding soft tissues, and potential benefits in promoting improved healing and postoperative outcomes. It will also focus on the role of (targeted) neoadjuvant therapies in the management of oral tumors, highlighting their potential to reduce tumor burden prior to surgery, improve resectability, and contribute to more favorable oncologic and functional results.