Malocclusions are well documented in domestic companion animals, yet reports in exotic and nondomestic species remain sparse. This case series describes the diagnosis and management of three unique malocclusion presentations in an Eastern grey kangaroo (Macropus giganteus), a Cougar (Puma concolor), and an Asian small-clawed otter (Aonyx cinereus). Each case highlights a different classification of malocclusion, associated pathology, and tailored treatment approach. The first case involved a kangaroo with a class IV asymmetric malocclusion resulting from developmental trauma. The abnormal occlusion caused repeated palatal trauma, necessitating both diagnostic imaging and corrective intervention to reduce pain and improve oral function. The second case, a cougar, presented with a class I malocclusion characterized by palatoversion of the maxillary fourth premolar teeth. This abnormal tooth positioning contributed to occlusal trauma and soft tissue contact lesions on the mandibular mucosa. Treatment considerations focused on preserving function while preventing progressive tissue damage. The third case involved an otter with a class III malocclusion and associated traumatic soft tissue injuries. Malpositioning of the dentition led to chronic lip trauma, soft tissue damage, and lip entrapment. Management required both endodontic intervention to restore comfort and normal oral mechanics. These cases underscore the importance of recognizing species-specific variations in occlusion and adapting treatment strategies beyond those commonly applied in small animal practice. By presenting a spectrum of malocclusion types across three diverse species, this case series emphasizes the need for careful clinical evaluation, creative problem-solving, and individualized treatment planning when managing oral health in exotic animals.